Maman Lab | Maman Lab

Welcome to Maman's lab

Genomic instability & Cancer

The necessary evil of genome instability

Genome instability is a hallmark of cancer. Our lab combines sensitive, high-throughput, genomic assays, and computational modeling, in order to crack the genomic code that drives genome instability in different cell-types, pathologies and conditions, and to grasp the landscape of DNA lesions in cancer.

Research

Immune repertoire formation – a double-edged sword

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Infection-induced genome instablity

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Genotoxicity to oncogenicity

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Recent Publications

Hanout-Chuiko, Wessal ; Pachakar, Sunil ; Foqara, Rawan et al. / The nonamer code for RAG-mediated recombination in vivo. In: Nucleic Acids Research. 2025 ; Vol. 53, No. 22.

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Sibony-Benyamini, Hadas ; Jbara, Rose ; Shubash Napso, Tania et al. / The landcape of Helicobacter pylori-mediated DNA breaks links bacterial genotoxicity to its oncogenic potential. In: Genome Medicine. 2025 ; Vol. 17, No. 1.

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Perez, Shira ; Lavi-Itzkovitz, Anat ; Gidoni, Moriah et al. / High-Resolution Genomic Profiling of Liver Cancer Links Etiology With Mutation and Epigenetic Signatures. In: CMGH. 2023 ; Vol. 16, No. 1. pp. 63-81.

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Tarsalainen, Alina ; Maman, Yaakov ; Meng, Fei Long et al. / Ig Enhancers Increase RNA Polymerase II Stalling at Somatic Hypermutation Target Sequences. In: Journal of Immunology. 2022 ; Vol. 208, No. 1. pp. 143-154.

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All Publications

Updates

We are hiring!

We are looking for highly motivated Ph.D. and M.Sc students to join us in studying the DNA lesion-to-cancer path

07/07/2025

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