The formation of antigen receptors during lymphocyte development is driven by extensive DNA editing processes crucial for the formation of the immune repertoire, namely – V(D)J recombination and Somatic Hypermutation.

Our focus lies on elucidating the mechanisms underlying the targeting and regulation of these processes across the genome, as well as identifying the factors that render specific genomic sites more susceptible to “off-target” activity, which has been associated with the development of lymphoid cancers.

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Hanout-Chuiko, Wessal ; Pachakar, Sunil ; Foqara, Rawan et al. / The nonamer code for RAG-mediated recombination in vivo. In: Nucleic Acids Research. 2025 ; Vol. 53, No. 22.

Tarsalainen, Alina ; Maman, Yaakov ; Meng, Fei Long et al. / Ig Enhancers Increase RNA Polymerase II Stalling at Somatic Hypermutation Target Sequences. In: Journal of Immunology. 2022 ; Vol. 208, No. 1. pp. 143-154.

Shinoda, Kenta ; Maman, Yaakov ; Canela, Andres et al. / Intra-Vκ Cluster Recombination Shapes the Ig Kappa Locus Repertoire. In: Cell Reports. 2019 ; Vol. 29, No. 13. pp. 4471-4481.e6.

Senigl, Filip ; Maman, Yaakov ; Dinesh, Ravi K. et al. / Topologically Associated Domains Delineate Susceptibility to Somatic Hypermutation. In: Cell Reports. 2019 ; Vol. 29, No. 12. pp. 3902-3915.e8.

Maman, Yaakov ; Teng, Grace ; Seth, Rashu et al. / RAG1 targeting in the genome is dominated by chromatin interactions mediated by the non-core regions of RAG1 and RAG2. In: Nucleic Acids Research. 2016 ; Vol. 44, No. 20. pp. 9624-9637.

Teng, Grace ; Maman, Yaakov ; Resch, Wolfgang et al. / RAG Represents a Widespread Threat to the Lymphocyte Genome. In: Cell. 2015 ; Vol. 162, No. 4. pp. 751-765.