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Welcome to Meir Shamay Lab website

How Viruses Promote Cancer Development?

Approximately 15% of cancer cases are linked to viral infections. The two herpes viruses we study, Kaposi’s sarcoma-associated herpesvirus (KSHV, also known as HHV-8) and Epstein-Barr virus (EBV, also known as HHV-4), are associated with an increasing number of human malignancies. The research interests in the lab are to study the functional interactions between viral proteins and the cellular machinery, which control both the viral life cycle and tumorigenesis.  The goal of our lab is to expand our knowledge of viral infections and to utilize this knowledge for the development and use of drugs that specifically target virally infected cells.

Fields of Interest

The effects of KSHV infection on host genome DNA methylation

Model for KSHV infection and DNA methylation

Directional recruitment between proteins

CRISPR-PITA

Viral Enhancers

Identification of KSHV enhancers

Recent Publications

Lavi, Ido ; Bhattacharya, Supriya ; Awase, Ankita et al. / Unidirectional recruitment between MeCP2 and KSHV-encoded LANA revealed by CRISPR/Cas9 recruitment assay. In: PLoS Pathogens. 2025 ; Vol. 21, No. 3.
Chowdhury, Nilabja Roy ; Shamay, Meir. / Viral Enhancers Orchestrate Kaposi's Sarcoma-Associated Herpesvirus Transcription. In: Journal of Medical Virology. 2025 ; Vol. 97, No. 7.
Roy Chowdhury, Nilabja ; Gurevich, Vyacheslav ; Shamay, Meir. / KSHV genome harbors both constitutive and lytically induced enhancers. In: Journal of Virology. 2024 ; Vol. 98, No. 6. pp. e0017924.
Cohen-Gulkar, Mazal ; David, Ahuvit ; Messika-Gold, Naama et al. / The LHX2-OTX2 transcriptional regulatory module controls retinal pigmented epithelium differentiation and underlies genetic risk for age-related macular degeneration. In: PLoS Biology. 2023 ; Vol. 21, No. 1.

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