Schematic presentation of the suggested model regarding KSHV infection and cellular DNA methylation.

KSHV infection leads to more methylation (hyper-methylation) and is followed by a slow decrease in methyaltion (hypo-methylation) during chronic infection and tumor development.

Journo G, Tushinsky C, Shterngas A, Avital N, Eran Y, Karpuj MV, Frenkel-Morgenstern M, Shamay M. Modulation of Cellular CpG DNA Methylation by Kaposi's Sarcoma-Associated Herpesvirus. J Virol. 2018 Jul 31;92(16):e00008-18. doi: 10.1128/JVI.00008-18.