Schematic illustration of the KSHV genome that includes the constitutive and lytic enhancers within the genome. Lytic enhancers are marked as red ovals, the constitutive enhancer is marked by a green oval, and the tissue-specific enhancer is marked by a blue oval. Arrows indicate the contribution of the enhancer to the lytic cycle. When RTA concentration is low, LANA binds to the TR and represses the lytic cycle. When RTA concentration is high, RTA binds the TR and activates its enhancer activity to turn on the lytic program.

Chowdhury, Nilabja Roy ; Shamay, Meir. / Viral Enhancers Orchestrate Kaposi's Sarcoma-Associated Herpesvirus Transcription. In: Journal of Medical Virology. 2025 ; Vol. 97, No. 7.