Publications
Straightforward Access to Terminally Disubstituted Electron-Deficient Alkylidene Cyclopent-2-en-4-ones through a Stepwise or Tandem Base-Promoted pseudo-Tsuji-Trost Allylation and Vinylogous retro-Michael Dehydrosulfinylation.
Trifonov L.; Rothstein A.; Korshin E. E.; Viskind O.; Afri M.; Leitus G.; Palczewski K.; Gruzman A., 2021
SH-29 and SK-119 attenuates air-pollution induced damage by activating Nrf2 in HaCaT cells.
Kahremany S.; Hofmann L.; Eretz-Kdosha N.; Silberstein E.; Gruzman A.*; Cohen G., 2021
Discovery and design of novel small molecule GSK-3 inhibitors targeting the substrate binding site.
Rippin I.; Khazanov N.; Ben Joseph S.; Kudinov T.; Berent E.; Marciano D.; Ruiz S. M. A.; Levy L.; Gruzman A.; Senderowitz H.; Eldar-Finkelman H., 2020
Novel sulfamoylbenzoates as antifungal agents against Malassezia furfur.
Trifonov L.; Chumin K.; Gvirtz R.; Afri M.; Korshin E.; Cohen G.*; Gruzman A., 2020
Development of chiral fluorinated alkyl derivatives of emixustat as drug candidates for the treatment of retinal degenerative diseases.
Blum E.; Zhang J.; Korshin E.; Palczewski K.; Gruzman A., 2020
A Lipophilic 4-Phenylbutyric Acid Derivative That Prevents Aggregation and Retention of Misfolded Proteins.
Azoulay-Ginsburg S.; Trobiani L.; Setini A.; Favaloro F.L.; Giorda E.; Jacob A.; Hauschner H.; Levy L.; Cestra G.; De Jaco A.; Gruzman A., 2020
Advances in Understanding the Initial Steps of Pruritoceptive Itch: How the Itch Hits the Switch.
Kahremany S.; Hofmann L.; Gruzman A.; Cohen G., 2020
Covered by Neuroligin-2-derived peptide polyamidoamine-based (PAMAM) dendrimers enhances pancreatic β-cells' proliferation and functions.
Munder A.; Moskovitz Y.; Meir A.; Kahremany S.; Cohen G.; Kolitz-Domb M .; Shtriker E.; Levy L.; Viskind O.; Lellouche J-P.; Senderowitz H.; Chessler S.; Korshin E.; Rothshtein S.; Gruzman A*., 2019
Activation of the Nrf2 by (E)-5-oxo-1-(4-((2,4,6-trihydroxybenzylidene)amino)phenyl)pyrrolidine-3-carboxylic acid attenuates, oxidative stress, UVB and LPS-induced damage.
Kahremany S.; Babaev I.; Gvirtz R.; Ogen-Stern N.; Azoulay-Ginsburg S.; Senderowitz H.; Cohen G.;* Gruzman A, 2019
Inhibiting the copper efflux system in microbes as a novel approach for developing antibiotics.
Meir A.; Lepechkin-Zilbermintz V.; Kahremany S.; Schwerdtfeger F.; Gevorkyan-Airapetov L.; Munder A.; Viskind O.; Gruzman A.*; Ruthstein S., 2019
Novel inhibitors of leukocyte transendothelial migration.
Getter T.; Margalit R.; Kahremany S.; Levy L.; Blum E.; Khazanov N.; Keshet-Levy N.Y.; Tamir T.Y.; Ben Major M.; Lahav R.; Zilber S.; Senderowitz H.; Bradfield P.; Imhof B.A.; Alpert E.; Gruzman A., 2019
Peptide-based development of PKA activators
Kahremany S.; Zhenin M.; Shenberger Y.; Maimoun D.; Colotti G.; Arad M.; Shainberg A.; Senderowitz H.; Ruthstein S*.; Gruzman A*., 2018
Hydrogel nanoparticles covered by neuroligin-2-derived peptide-protected β-cells under oxidative stress and increase their proliferation.
Shtriker E.; Bretler S.; Munder A.; Byk G.; Cohen G.; Kolitz-Domb M.; Gruzman A*., 2018
An Expedient Synthesis of CMF-019: (S)-5-Methyl-3-{1-(pentan-3-yl)-2-(thiophen-2-ylmethyl)-1H-benzo[d]imidazole-5-carboxamido}hexanoic acid, an Apelin Receptor (APJ) Agonist.
Trifonov L.; Afri M.; Palczewski K.; Korshin E*. and Gruzman A*., 2018
Computer-aided design and synthesis of (1-(4-((3,4-dihydroxybenzylidene)amino)phenyl)-5-oxopyrrolidine-3-carboxylic acid) as a novel Nrf2 enhancer.
Kahremany S.; Babaev I.; Hasin P.; Tamir T.; Ben-Zur T.; Cohen G.; Jiang Z.; Weintraub S.; Offen D.; Rahimipour S.; Major B.; Senderowitz H.; Gruzman A*., 2018
A novel phenylchromane derivative increases the rate of glucose uptake in L6 myotubes and augments insulin secretion in pancreatic beta-cells by activating AMPK.
Rozentul, N.; Avrahami, Y.; Shubely, M.; Levy, L.; Munder, A.; Cohen, G.; Cerasi, E.; Sasson, S*.; Gruzman, A*. , 2017