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Gruzman Lab

The Drug Development Lab

Our research group takes a multidisciplinary approach to developing new drug candidates, combining pharmacology, molecular biology, biochemistry, molecular modeling, and nanotechnology. We begin by identifying a key target protein involved in a disease, using its 3D structure to design potential small molecules through computer modeling. These molecules are synthesized, tested in vitro, and evaluated for therapeutic effects in animal models—all conducted in our lab. We strive to combat devastating diseases, driven by the belief that medicinal chemistry can improve human health and well-being.

Fields of interest

Metal–Peptide Complexes as Synthetic Oxygen Carriers for Artificial Blood

Novel Alkylating Agent for Effective Glioblastoma Therapy

Development of the leukocyte transendothelial migration inhibitors

Development of novel Nrf-2 activators (Nrf-2/KEAP1 interaction blockers)

Development of bioactive peptides and peptide based research tools.

Human α1-antitrypsin based therapeutic peptides as a novel wound healing treatment.

Development of novel chemical chaperones as drug candidates against misfolded proteins related diseases.

Green recycling of wastewaters through cutting-edge microalgae and plant cultivation systems in extreme environments.

Updates!

Congrats!

Dr. Laura Nissim-Levy received a promotion in her research staff rank at Bar-Ilan University.

Congrats!

Congratulations to Dr. Ayelet Rotshtein and her family on the arrival of their baby boy!

Congrats!

Prof. Albeck and Prof. Gruzman have been awarded a two-year research grant from the Andre Danesh Artificial Blood Institute, Massachusetts, USA.

Congrats!

Congratulations to Alisa Govtvan on being awarded the BIU President's Fellowship!

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