Publications
Unified Synthesis of Electron-Deficient 1,4- and 1,1,4-Substituted 1,3-Dienes through a Base-Promoted Allylation Followed by Retro-Michael Vinylogous Dehydrosulfinylation
Rothstein A., Trifonov L, Kedar N., Afri M., Korshin E.E.,* Gruzman* A., 2024
Intracellular spatially-targeted chemical chaperones increase native state stability of mutant SOD1 barrel
Ribeiro S.; Gnutt D.; Azoulay-Ginsburg S.; Zamira Fetahaj Z.; Spurlock E.; Lindner F.; Kuz D.; Cohen-Erez Y.; Rapaport H.; Israelson A.; Gruzman A*.; Ebbinghaus S*., 2023
A novel facial cream based on skin penetrable Hemp oil microparticles
Lubart R.; Yariv I.; Fixler D.; Rothstein A.; Gruzman A.; Lipovsky A.*, 2023
Moderately lipophilic 2-(Het)aryl-6-dithioacetals, 2-phenyl-1,4-benzodioxane-6-dithioacetals and 2-phenylbenzofuran-5-dithioacetals: Synthesis and primary evaluation as potential antidiabetic AMPK-activators.
Lepechkin-Zilbermintz V.; Bareket B.; Gonnord V.; Steffen A.; Morice C.; Michaut M.; Munder A.; Korshin E. E.; Contreras J-M.; Cerasi E.; Sasson S.; Gruzman A.*, 2023
4-Phenylbutyric Acid (4-PBA) Derivatives Prevent SOD1 Amyloid Aggregation In Vitro with No Effect on Disease Progression in SOD1-ALS Mice.
Alfahel L.; Argueti-Ostrovsky S.; Barel S.; Ali Saleh M.; Kahn J.; Azoulay-Ginsburg S.; Rothstein A.; Ebbinghaus S.; Gruzman A.; Israelson A*., 2022
Dinkova-Kostova A. Nrf2 in dermatological disorders: pharmacological activation for protection against cutaneous photodamage and photodermatosis.
Kahremany S.; Hofmann L.; Gruzman A.; Cohen G., 2022
Dinkova-Kostova A. Nrf2 in dermatological disorders: pharmacological activation for protection against cutaneous photodamage and photodermatosis.
Kahremany S.; Hofmann L.; Gruzman A.; Cohen G., 2022
Benzyl-para-di-[5-methyl-4-(n-octylamino)pyrimidin-2(1H)one] as an Interferon beta (IFN-β) modulator.
Trifonov L.; Yurchenko M.; Skjesol A.; Cohen G.; Espevik T.; Korshin E. E.; Husebye H.;* Gruzman A., 2022
Development of anti-inflammatory peptidomimetics based on the structure of human alpha1-antitrypsin.
Lior Y.; Shtriker E.; Kahremany S.; Lewis E.; Gruzman A., 2022
Rational Alteration of Pharmacokinetics of Chiral Fluorinated and Deuterated Derivatives of Emixustat for Retinal Therapy.
Blum E.; Zhang J.; Zaluski J.; Einstein D.; E., Korshin E. E.; Kubas A.; Gruzman A.; Tochtrop G. P.; Kiser P. D.; Palczewski K., 2021
Chemical Chaperones Targeted to ER and Lysosome Prevented Neurodegeneration in a C9orf72 Repeat Expansion Drosophila ALS Model.
Azoulay-Ginsburg S.; Di Salvio M.; Ribeiro S.; Weitman M.; Afri M.; Ebbinghaus S.; Cestra G.; Gruzman A., 2021
Investigation of the membrane fluidity regulation of fatty acid intracellular distribution by fluorescence lifetime imaging of polarity sensitive fluorescent analogs of fatty acids/laurdan.
Bianchetti G.; Azoulay-Ginsburg S.; Keshet-Levy N. Y.; Malka A.; Zilber S.; Korshin E. E.; Sasson S.; De Spirito M.; Gruzman A.; Maulucci G., 2021
A potent leukocyte transmigration blocker: GT-73 showed a protective effect against LPS-induced ARDS in mice.
Blum E.; Margalit R.; Levy L.; Getter T.; Lahav R.; Zilber S.; Bradfield P.; Imhof B. A.; Alpert E.; Gruzman A., 2021
Multifunctionality of Prostatic Acid Phosphatase in Prostate Cancer Pathogenesis.
Alpert E.; Akhavan A.; Gruzman A.; Hansen W. J.; Lehrer- Graiwer J.; Witkowski H. E.; Hall S.C.; Johansen E.; McAllister S.; Gulati M.; Lin M-F.; Lingappa V.R*., 2021
Straightforward Access to Terminally Disubstituted Electron-Deficient Alkylidene Cyclopent-2-en-4-ones through a Stepwise or Tandem Base-Promoted pseudo-Tsuji-Trost Allylation and Vinylogous retro-Michael Dehydrosulfinylation.
Trifonov L.; Rothstein A.; Korshin E. E.; Viskind O.; Afri M.; Leitus G.; Palczewski K.; Gruzman A., 2021
SH-29 and SK-119 attenuates air-pollution induced damage by activating Nrf2 in HaCaT cells.
Kahremany S.; Hofmann L.; Eretz-Kdosha N.; Silberstein E.; Gruzman A.*; Cohen G., 2021