Publications
Thiophene-Benzimidazole Conjugates Attenuate IL-33-induced Inflammation in Human Mast Cell Line and in ex vivo Human Skin Organ Cultures.
Gvirtz R., Kahremany S., Trifonov L., Weintraub S., Korshin E.E., Silberstein E., Shtil N., Kompanets M., Ayzenberg T., Ogen-Shtern N., Cohen G.,* Gruzman* A. , 2026
Medicinal Chemistry Projects Funding in Academia.
Rothstein A., Chorghade M., Ibrahim H., Ganesan A., Erhardt P., Schnorrenberg G., Gruzman* A, 2025
Evaluation of the Recent Dynamics for Funding Medicinal Chemistry Projects in Academia. Results of a Survey Conducted by IUPAC Division VII (Chemistry and Human Health)
Ayelet Rothstein, Mukund Chorghade, Hassan Ibrahim, A. Ganesan, Paul W. Erhardt, Gerd Schnorrenberg and Arie Gruzman, 2025
A novel 2-oxopyrrolidine derivative (LN-53) efficiently induces Nrf-2 signaling pathway activation in human epidermal keratinocytes
Laura Nissim, Basak Ezgi Sarac, Dilara Karaguzel, Gokhan Arik, Shirin Kahremany, Edward E. Korshin, Arie Gruzman & Cagatay Karaaslan , 2025
Unified Synthesis of Electron-Deficient 1,4- and 1,1,4-Substituted 1,3-Dienes through a Base-Promoted Allylation Followed by Retro-Michael Vinylogous Dehydrosulfinylation
Rothstein A., Trifonov L, Kedar N., Afri M., Korshin E.E.,* Gruzman* A., 2024
A novel facial cream based on skin penetrable Hemp oil microparticles
Lubart R.; Yariv I.; Fixler D.; Rothstein A.; Gruzman A.; Lipovsky A.*, 2023
Moderately lipophilic 2-(Het)aryl-6-dithioacetals, 2-phenyl-1,4-benzodioxane-6-dithioacetals and 2-phenylbenzofuran-5-dithioacetals: Synthesis and primary evaluation as potential antidiabetic AMPK-activators.
Lepechkin-Zilbermintz V.; Bareket B.; Gonnord V.; Steffen A.; Morice C.; Michaut M.; Munder A.; Korshin E. E.; Contreras J-M.; Cerasi E.; Sasson S.; Gruzman A.*, 2023
Intracellular spatially-targeted chemical chaperones increase native state stability of mutant SOD1 barrel
Ribeiro S.; Gnutt D.; Azoulay-Ginsburg S.; Zamira Fetahaj Z.; Spurlock E.; Lindner F.; Kuz D.; Cohen-Erez Y.; Rapaport H.; Israelson A.; Gruzman A*.; Ebbinghaus S*., 2023
Development of anti-inflammatory peptidomimetics based on the structure of human alpha1-antitrypsin.
Lior Y.; Shtriker E.; Kahremany S.; Lewis E.; Gruzman A., 2022
Benzyl-para-di-[5-methyl-4-(n-octylamino)pyrimidin-2(1H)one] as an Interferon beta (IFN-β) modulator.
Trifonov L.; Yurchenko M.; Skjesol A.; Cohen G.; Espevik T.; Korshin E. E.; Husebye H.;* Gruzman A., 2022
NRF2 in dermatological disorders: Pharmacological activation for protection against cutaneous photodamage and photodermatosis
Kahremany S.; Hofmann L.; Gruzman A.; Cohen G., 2022
4-Phenylbutyric Acid (4-PBA) Derivatives Prevent SOD1 Amyloid Aggregation In Vitro with No Effect on Disease Progression in SOD1-ALS Mice.
Alfahel L.; Argueti-Ostrovsky S.; Barel S.; Ali Saleh M.; Kahn J.; Azoulay-Ginsburg S.; Rothstein A.; Ebbinghaus S.; Gruzman A.; Israelson A*., 2022
Development and characterisation of SMURF2-targeting modifiers.
Manikoth Ayyathan D.; Levy-Cohen G.; Shubely M.; Boutros-Suleiman S.; Lepechkin-Zilbermintz V.; Shokhen M.; Albeck A.; Gruzman A.; Blank M., 2021
Dermal Itch in Psoriasis and Atopic Dermatitis: Current Treatments and New Perspectives.
Kahremany S.; Hofmann L.; Harari M, Gruzman A.; Cohen G., 2021
Chemical Chaperones Targeted to ER and Lysosome Prevented Neurodegeneration in a C9orf72 Repeat Expansion Drosophila ALS Model.
Azoulay-Ginsburg S.; Di Salvio M.; Ribeiro S.; Weitman M.; Afri M.; Ebbinghaus S.; Cestra G.; Gruzman A., 2021
Rational Alteration of Pharmacokinetics of Chiral Fluorinated and Deuterated Derivatives of Emixustat for Retinal Therapy.
Blum E.; Zhang J.; Zaluski J.; Einstein D.; E., Korshin E. E.; Kubas A.; Gruzman A.; Tochtrop G. P.; Kiser P. D.; Palczewski K., 2021