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Drug Development Lab

Gruzman Lab

The Drug Development Lab

Our research group takes a multidisciplinary approach to developing new drug candidates, combining pharmacology, molecular biology, biochemistry, molecular modeling, and nanotechnology. We begin by identifying a key target protein involved in a disease, using its 3D structure to design potential small molecules through computer modeling. These molecules are synthesized, tested in vitro, and evaluated for therapeutic effects in animal models—all conducted in our lab. We strive to combat devastating diseases, driven by the belief that medicinal chemistry can improve human health and well-being.

Fields of interest

Recent Publications

Unified Synthesis of Electron-Deficient 1,4- and 1,1,4-Substituted 1,3-Dienes through a Base-Promoted Allylation Followed by Retro-Michael Vinylogous Dehydrosulfinylation

Rothstein A., Trifonov L, Kedar N., Afri M., Korshin E.E.,* Gruzman* A. , 2024

Intracellular spatially-targeted chemical chaperones increase native state stability of mutant SOD1 barrel

Ribeiro S.; Gnutt D.; Azoulay-Ginsburg S.; Zamira Fetahaj Z.; Spurlock E.; Lindner F.; Kuz D.; Cohen-Erez Y.; Rapaport H.; Israelson A.; Gruzman A*.; Ebbinghaus S*. , 2023

A novel facial cream based on skin penetrable Hemp oil microparticles

Lubart R.; Yariv I.; Fixler D.; Rothstein A.; Gruzman A.; Lipovsky A.* , 2023

Moderately lipophilic 2-(Het)aryl-6-dithioacetals, 2-phenyl-1,4-benzodioxane-6-dithioacetals and 2-phenylbenzofuran-5-dithioacetals: Synthesis and primary evaluation as potential antidiabetic AMPK-activators.

Lepechkin-Zilbermintz V.; Bareket B.; Gonnord V.; Steffen A.; Morice C.; Michaut M.; Munder A.; Korshin E. E.; Contreras J-M.; Cerasi E.; Sasson S.; Gruzman A.* , 2023

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Video Competition Lab

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