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The Okun Lab

Neuroimmunology is the most rapidly advancing field of research in the study of brain diseases and particularly in Alzheimer’s disease. We are studying how immune cells interact with the brain during Aging, in Alzheimer’s disease and in individuals with Down syndrome. We also study the mechanistic link between pregnancy with a Down syndrome fetus and the elevated risk of maternal cognitive decline.

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Our research

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Meningeal Immunity in Alzheimer’s Disease and Aging

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Does immune dysregulation affect cognition in Down Syndrome?

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Why does pregnancy with a Down Syndrome fetus promote maternal Alzheimer’s Disease?

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Preventing maternal cognitive decline in mother to Down syndrome children using vaccines

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Feto-maternal transfer of Extracellular Vesicles (EVs) as mediators of maternal cognitive decline

The Okun Laboratory for Alzheimer's disease research