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Biological Network Systems

Orr Lab

Biological Network Systems

Our research lab is interdisciplinary, dedicated to unraveling the complexities of complex biological network systems, with a particular focus on gene regulatory networks, aging, and physiological networks. We develop innovative computational methodologies drawn from a variety of fields, including artificial intelligence, computational biology, ecology, nonlinear dynamics, statistical mechanics, and especially network science. We rigorously validate our theories and approaches through carefully designed biological experiments conducted in our lab. Our ultimate goal is to enhance our understanding of tissue biology and physiology, leading to improved diagnostics and therapeutics that can significantly advance patient care. Central to our research is the exploration of the intricate relationships between the structure and dynamics of complex networks, which are fundamental to tissue function and stability.

Fields of Interest

Recent Publications

Nucleation phenomena and extreme vulnerability of spatial k-core systems. Nature Communications

L Xue, S Gao, LK Gallos, O Levy, B Gross, Z Di, S Havlin , 2024

Nature of epigenetic aging from a single-cell perspective. Nature aging.

Andrei E Tarkhov, Thomas Lindstrom-Vautrin, Sirui Zhang, Kejun Ying, Mahdi Moqri, Bohan Zhang, Alexander Tyshkovskiy, Orr Levy, Vadim N Gladyshev , 2024

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