Cytosolic ascorbate peroxidases (APXs) are important regulators of cellular hydrogen peroxide levels and redox homeostasis. We investigate the regulation and biological functions of cytosolic APXs to understand how individual APX isoforms contribute to plant responses to environmental and developmental signals. We are particularly interested in uncovering functions of these enzymes that extend beyond their classical role in ROS detoxification and in defining their connections to broader cellular and metabolic pathways.  

Selected publication:

1. Double Mutants Deficient in Cytosolic and Thylakoid Ascorbate Peroxidase Reveal a Complex Mode of Interaction between Reactive Oxygen Species, Plant Development, and Response to Abiotic Stresses. 2007. Miller G., Suzuki N., Rizhsky L., Hegie A., Koussevitzky S., Mittler R. Plant Physiology 144 (4), 1777-1785   Link

2. Enhanced seed production under prolonged heat stress conditions in Arabidopsis thaliana plants deficient in cytosolic ascorbate peroxidase 2. 2013. Suzuki N., Miller G., Sejima H., Harper J., Mittler R. Journal of Experimental Botany 64 (1), 253-263.   Link

3. ASCORBATE PEROXIDASE6 protects Arabidopsis desiccating and germinating seeds from stress and mediates crosstalk between reactive oxygen species, abscisic acid, and auxin. 2014. Chen C, Letnik I, Hacham Y, Dobrev P, Ben-Daniel BH, Vanková R, Amir R, Miller G. Plant Physiology 166 (1), 370-383.   Link

4. ASCORBATE PEROXIDASE6 delays the onset of age-dependent leaf senescence. 2021. Chen C, Galon Y, Rahmati Ishka M, Malihi S, Shimanovsky V, Twito S, Rath A, Vatamaniuk OK, Miller G. Plant Physiology 185 (2), 441-456. Link