The Roichman Lab studies how diet and the gut microbiome interact to generate bioactive metabolites that shape liver function, metabolism, cancer development, and therapeutic response. We combine in vitro and in vivo models with state-of-the-art HPLC, high-resolution LC–MS, and computational approaches to identify novel metabolites at the diet-microbiome-host axis and define their impact on health and disease.
Our Research
Metabolite Discovery
Liver Metabolism & Pharmacology
Cancer & Therapeutic Response
Recent Publications
Language model-guided anticipation and discovery of mammalian metabolites. / Qiang, Hantao; Wang, Fei; Lu, Wenyun et al.
In: Nature, 14.01.2026.
In: Nature, 14.01.2026.
Research output: Contribution to journal › Article › peer-review
Targeting autocrine retinoic acid signaling by ALDH1A2 inhibition enhances antitumor dendritic cell vaccine efficacy. / Fang, Cao; Esposito, Mark; Hars, Ulrike et al.
In: Nature Immunology, Vol. 27, No. 2, 02.2026, p. 250-264.
In: Nature Immunology, Vol. 27, No. 2, 02.2026, p. 250-264.
Research output: Contribution to journal › Article › peer-review
Dietary Fiber Lacks a Consistent Effect on Immune Checkpoint Blockade Efficacy Across Diverse Murine Tumor Models. / Roichman, Asael; Reyes-Castellanos, Gabriela; Chen, Ziqing et al.
In: Cancer Research, Vol. 85, No. 17, 02.09.2025, p. 3335-3347.
In: Cancer Research, Vol. 85, No. 17, 02.09.2025, p. 3335-3347.
Research output: Contribution to journal › Article › peer-review
Sirt6 prevents the age-related decline of H2S through the control of one-carbon metabolism. / Touitou, Noga; Nahum, Liat; Feldman-Trabelsi, Sarit et al.
In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 122, No. 46, e2514084122, 18.11.2025.
In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 122, No. 46, e2514084122, 18.11.2025.
Research output: Contribution to journal › Article › peer-review