The Copper Metabolism Lab
In our lab, we utilize various biophysical methods, such as EPR, NMR, CD, together with biochemical experiments, and computational methods to study the cellular copper cycle in detail in eukaryotic and prokaryotic systems. The knowledge gained is then used to develop novel biomarkers and therapeutic compounds. All experiments from the protein expression and purification stage till the cellular and mice level are conducted in house by the lab group members.
Fields of Interest
The copper cycle in eukaryotic systems
The copper cycle in prokaryotic systems
Developing 64Cu-based radiotracers
The effect of copper on crop yield
Recent Publications
An efficient EPR spin-labelling method enables insights of conformational changes in DNA.
Tracking disordered extracellular domains of membrane proteins in the cell with Cu(II)-based spin-labels.
The dynamic plasticity of P. aerguinosa CueR copper transcription factor upon cofactor and DNA binding.
An in-cell spin-labelling methodology provides structural information on cytoplasmic proteins in bacteria.
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