Karasik Lab

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Welcome to The Musculoskeletal Genetics Lab

Karasik Lab

The primary objective of our research is to understand the biology reflected in the complex pathology of musculoskeletal aging and disease. Our research focuses on identifying genes underlying the heritable variation of human complex traits, such as susceptibility to osteoporotic fractures, muscle wasting, and metabolic syndrome.  Zebrafish (Danio rerio) serves as a valuable model for the cross-talk between these organs and tissues.

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Fields of Interest

About our research

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Human Musculoskeleton

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Multi-ancestry whole genome sequencing analysis of lean body masshole genome sequencing analysis of lean body mass

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Recent Publications

Donaka, Rajashekar ; Zheng, Houfeng ; Ackert-Bicknell, Cheryl L. et al. / Early life lipid overload in Native American Myopathy is phenocopied by stac3 knockout in zebrafish. In: Gene. 2025 ; Vol. 936.
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Morani, Ilham ; Shibli, Haneen ; Karasik, David et al. / Determining population-specific risk factors for COVID-19 susceptibility and severity to inform future individual-level integrated risk scoring. In: BMC Infectious Diseases. 2025 ; Vol. 25, No. 1.
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Zhang, Xiaoyu ; Su, Kuan Jui ; Banerjee, Bodhisattwa et al. / Multi-ancestry whole genome sequencing analysis of lean body mass. In: Genome Biology. 2025 ; Vol. 26, No. 1.
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Alvarado, Kurtis ; Tang, W. Joyce ; Watson, Claire J. et al. / Loss of cped1 does not affect bone and lean tissue in zebrafish. In: JBMR Plus. 2025 ; Vol. 9, No. 2.
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