Karasik Lab

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Karasik Lab

Welcome to The Musculoskeletal Genetics Lab

Karasik Lab

The primary objective of our research is to understand the biology reflected in the complex pathology of musculoskeletal aging and disease. Our research focuses on identifying genes underlying the heritable variation of human complex traits, such as susceptibility to osteoporotic fractures, muscle wasting, and metabolic syndrome.  Zebrafish (Danio rerio) serves as a valuable model for the cross-talk between these organs and tissues.

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Fields of Interest

About our research

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Human Musculoskeleton

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Multi-ancestry whole genome sequencing analysis of lean body masshole genome sequencing analysis of lean body mass

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Recent Publications

International Federation of Musculoskeletal Research Societies (IFMRS) Big Data Working Group. / Multiscale analysis and functional validation of the cellular and genetic determinants of skeletal disease. In: Nature Genetics. 2026 ; Vol. 58, No. 7. pp. 1530-1545.
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Rivas, Daniel ; Baltasar-Fernandez, Ivan ; AlOkda, Abdelrahman et al. / Picolinic acid, a tryptophan metabolite, exhibits anabolic effects in muscle cells and improves lifespan and movement in C. elegans. In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 2026 ; Vol. 81, No. 1.
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Wei, Peng ; Zhao, Pianpian ; Gu, Zenghui et al. / Might modulation of the endocannabinoid system provide a potential dual therapeutic strategy for osteoporosis and depression?. In: General Psychiatry. 2026 ; Vol. 39, No. 4.
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Zhang, Xiaoyu ; Su, Kuan Jui ; Banerjee, Bodhisattwa et al. / Multi-ancestry whole genome sequencing analysis of lean body mass. In: Genome Biology. 2025 ; Vol. 26, No. 1.
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