Our lab explores the biology of tissues and organs through the lens of single-cell genomics. We develop cutting-edge technologies and computational tools to uncover the cellular and molecular mechanisms that drive development, regeneration, and cancer. Our goal is to advance early detection of complex disease, enable personalized therapies, and contribute to regenerative medicine by understanding biology at single-cell resolution.

Tissues and organs are built from many distinct cell types, each playing a unique role. Their precise coordination is essential for normal development, ongoing maintenance, and repair throughout life. When this harmony is disrupted—as in the case of cancer—the result is a set of complex and still poorly understood diseases that can vary widely between individuals.

In our lab, we aim to unravel this complexity. We use single-cell technologies and next-generation sequencing to break down tissues and tumors into their individual cellular components. By analyzing gene expression and genomic data from each cell, we identify distinct cell types, trace their developmental paths, decipher the regulatory mechanisms guiding their behavior, and map the intricate networks of interactions between them.

Our research focuses on three core goals:

1. Discovering the cellular and molecular mechanisms that control development, regeneration, and cancer.

2.  Identifying biomarkers for early diagnosis, monitoring, and targeted treatment of complex disease.

3. Understanding tumor heterogeneity to guide the development of personalized cancer treatments.

By building comprehensive single-cell profiles of embryonic, adult, and diseased tissues, we aim to uncover the hidden logic of how our bodies are built, repaired—and sometimes, how they malfunction.